By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators publish new report on Colon Cancer. According to news originating from Corvallis, Oregon, by NewsRx correspondents, researchers stated "Capsaicin is a pungent ingredient in chili red peppers and has been linked to suppression of growth in various cancer cells. However, the underlying mechanism(s) by which capsaicin induces growth arrest and apoptosis of cancer cells is not completely understood."
Our news journalists obtained a quote from the research by the authors from Oregon State University, "In the present study, we investigated whether capsaicin alters beta-catenin-dependent signaling in human colorectal cancer cells in vitro. Exposure of SW480. LoVo and HCT-116 cells to capsaicin suppressed cell proliferation. Transient transfection with a beta-catenin/T-cell factor (TCF)-responsive reporter indicated that capsaicin suppressed the transcriptional activity of beta-catenin/TCF. Capsaicin treatment resulted in a decrease of intracellular beta-catenin levels and a reduction of transcripts from the beta-catenin gene (CTNNB1). These results were confirmed by a reduced luciferase reporter activity driven by promoter-reporter construct containing the promoter region of the Catnb gene. In addition, capsaicin destabilized beta-catenin through enhancement of proteosomal-dependent degradation. Western blot and immunoprecipitation studies indicated that capsaicin treatment suppressed TCF-4 expression and disrupted the interaction of TCF-4 and beta-catenin."
According to the news editors, the researchers concluded: "This study identifies a role for the beta-catenin/TCF-dependent pathway that potentially contributes to the anticancer activity of capsaicin in human colorectal cancer cells."
For more information on this research see: Capsaicin represses transcriptional activity of beta-catenin in human colorectal cancer cells. Journal of Nutritional Biochemistry, 2012;23(6):646-655. Journal of Nutritional Biochemistry can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Journal of Nutritional Biochemistry - www.elsevier.com/wps/product/cws_home/525013)
The news correspondents report that additional information may be obtained from S.H. Lee, Oregon State University, Linus Pauling Inst, Corvallis, OR 97331, United States (see also Colon Cancer).
Keywords for this news article include: Oregon, Oncology, Corvallis, Capsaicin, Catechols, Colorectal, Colon Cancer, Hydrocarbons, beta Catenin, United States, Gastroenterology, Organic Chemicals, Transcription Factors, North and Central America, Armadillo Domain Proteins, Polyunsaturated Alkamides
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2012, NewsRx LLC
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Source: http://www.lef.org/news/LefDailyNews.htm?NewsID=14039&Section=Disease
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